Title : Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor.

Pub. Date : 2010 Feb 19

PMID : 20007715






7 Functional Relationships(s)
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1 Here we demonstrate that a conserved proline, Pro(247), in TM6 of platelet-activating factor receptor (PAFR) is required for endoplasmic reticulum (ER) export and trafficking after agonist-induced internalization. Proline platelet activating factor receptor Homo sapiens
2 Here we demonstrate that a conserved proline, Pro(247), in TM6 of platelet-activating factor receptor (PAFR) is required for endoplasmic reticulum (ER) export and trafficking after agonist-induced internalization. Proline platelet activating factor receptor Homo sapiens
3 Here we demonstrate that a conserved proline, Pro(247), in TM6 of platelet-activating factor receptor (PAFR) is required for endoplasmic reticulum (ER) export and trafficking after agonist-induced internalization. Proline platelet activating factor receptor Homo sapiens
4 Here we demonstrate that a conserved proline, Pro(247), in TM6 of platelet-activating factor receptor (PAFR) is required for endoplasmic reticulum (ER) export and trafficking after agonist-induced internalization. Proline platelet activating factor receptor Homo sapiens
5 Because a PAFR antagonist, Y-24180, acted as a pharmacological chaperone to rescue ER retention, this retention is due to misfolding of PAFR. 4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine platelet activating factor receptor Homo sapiens
6 Because a PAFR antagonist, Y-24180, acted as a pharmacological chaperone to rescue ER retention, this retention is due to misfolding of PAFR. 4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine platelet activating factor receptor Homo sapiens
7 These results demonstrate that the conserved proline in TM6 is crucial for intracellular trafficking of PAFR. Proline platelet activating factor receptor Homo sapiens