Pub. Date : 2010 Jan 27
PMID : 19925453
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 3OC12 and the Ca2+ ionophore A23187 caused a rapid cytosolic Ca2+ influx and down-regulated PON2 mRNA, protein and hydrolytic activity in A549 and EA.hy 926 cells. | Calcimycin | paraoxonase 2 | Homo sapiens |
| 2 | The Ca2+ chelator BAPTA/AM [1,2-bis-(o-aminophenoxy)ethane-N,N,N",N"-tetra-acetic acid tetrakis(acetoxymethyl ester)] diminished the ability of 3OC12 to decrease PON2, demonstrating that the effects are mediated by Ca2+. | 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid | paraoxonase 2 | Homo sapiens |
| 3 | PON2 also has antioxidative properties and we show that it protects cells from pyocyanin-induced oxidative stress. | Pyocyanine | paraoxonase 2 | Homo sapiens |
| 4 | Knockdown of PON2 by transfecting cells with siRNA (small interfering RNA) rendered them more sensitive to, whereas overexpression of PON2 protected cells from, pyocyanin-induced ROS formation. | Pyocyanine | paraoxonase 2 | Homo sapiens |
| 5 | Knockdown of PON2 by transfecting cells with siRNA (small interfering RNA) rendered them more sensitive to, whereas overexpression of PON2 protected cells from, pyocyanin-induced ROS formation. | Pyocyanine | paraoxonase 2 | Homo sapiens |
| 6 | Knockdown of PON2 by transfecting cells with siRNA (small interfering RNA) rendered them more sensitive to, whereas overexpression of PON2 protected cells from, pyocyanin-induced ROS formation. | Reactive Oxygen Species | paraoxonase 2 | Homo sapiens |
| 7 | Knockdown of PON2 by transfecting cells with siRNA (small interfering RNA) rendered them more sensitive to, whereas overexpression of PON2 protected cells from, pyocyanin-induced ROS formation. | Reactive Oxygen Species | paraoxonase 2 | Homo sapiens |
| 8 | Additionally, 3OC12 potentiated pyocyanin-induced ROS formation, presumably by inactivating PON2. | Pyocyanine | paraoxonase 2 | Homo sapiens |
| 9 | Additionally, 3OC12 potentiated pyocyanin-induced ROS formation, presumably by inactivating PON2. | Reactive Oxygen Species | paraoxonase 2 | Homo sapiens |