Pub. Date : 1991 Feb 15
PMID : 1991962
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Over a wide range of concentrations (10(-5) to 10(-8) M), DXS inhibited the production of MCAF at the mRNA and protein level in a human fibrosarcoma cell line, which was stimulated with either IL-1 or TNF-alpha. | Dexamethasone | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | In addition, a nuclear run-off analysis revealed that DXS also inhibited the transcription of IL-1- or TNF-activated MCAF genes. | Dexamethasone | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | Therefore, both the destabilization of MCAF mRNA and the inhibition of transcription of the gene contribute to the decrease in the MCAF mRNA steady state level by DXS. | Dexamethasone | C-C motif chemokine ligand 2 | Homo sapiens |
| 4 | Therefore, both the destabilization of MCAF mRNA and the inhibition of transcription of the gene contribute to the decrease in the MCAF mRNA steady state level by DXS. | Dexamethasone | C-C motif chemokine ligand 2 | Homo sapiens |