Title : A new role for the transferrin receptor in the release of iron from transferrin.

Pub. Date : 1991 Jan 15

PMID : 1988034






4 Functional Relationships(s)
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1 Iron removal by pyrophosphate from human serum diferric transferrin and the complex of transferrin with its receptor was studied in 0.05 M HEPES or MES buffers containing 0.1 M NaCl and 0.01 M CHAPS at 25 degrees C at pH 7.4, 6.4, and 5.6. diphosphoric acid transferrin Homo sapiens
2 Iron removal of 0.05 M pyrophosphate at pH 7.4 from diferric transferrin bound to the receptor is considerably slower than that from free diferric transferrin, with observed pseudo-first-order rate constants of 0.020 and 0.191 min-1, respectively. diphosphoric acid transferrin Homo sapiens
3 However, at pH 5.6, iron removal by 0.001 M pyrophosphate is faster from diferric transferrin bound to its receptor than from free transferrin (observed rate constants of 0.819 and 0.160 min-1, respectively). diphosphoric acid transferrin Homo sapiens
4 However, at pH 5.6, iron removal by 0.001 M pyrophosphate is faster from diferric transferrin bound to its receptor than from free transferrin (observed rate constants of 0.819 and 0.160 min-1, respectively). diphosphoric acid transferrin Homo sapiens