Title : 8-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: implications for treatment of Carney complex-associated tumors.

Pub. Date : 2009 Oct

PMID : 19773399






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The cAMP analogue 8-Cl-adenosine (8-Cl-ADO) is thought to inhibit cancer cell proliferation. 8-chloroadenosine cathelicidin antimicrobial peptide Homo sapiens
2 The cAMP analogue 8-Cl-adenosine (8-Cl-ADO) is thought to inhibit cancer cell proliferation. 8-chloroadenosine cathelicidin antimicrobial peptide Homo sapiens
3 PKA activity, cAMP levels, and (3)H-cAMP binding were increased or decreased, respectively, by 8-Cl-ADO, whereas PKA subunit levels were differentially affected. 8-chloroadenosine cathelicidin antimicrobial peptide Homo sapiens
4 CONCLUSIONS: 8-Cl-ADO in addition to unambiguously inhibiting proliferation and inducing apoptosis in a PKA-independent manner also has PKA-dependent effects that are unmasked by a mutant PRKAR1A. 8-chloroadenosine protein kinase cAMP-dependent type I regulatory subunit alpha Homo sapiens