Title : (2,6-Dimethylphenylsulphonyl)nitromethane: a new structural type of aldose reductase inhibitor which follows biphasic kinetics and uses an allosteric binding site.

Pub. Date : 1991 Nov 6

PMID : 1958230






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Many of the complications of diabetes seem to be due to aldose reductase (aldehyde reductase 2, ALR2) catalysing the increased conversion of glucose to sorbitol. Glucose lens aldose reductase pseudogene Bos taurus
2 Many of the complications of diabetes seem to be due to aldose reductase (aldehyde reductase 2, ALR2) catalysing the increased conversion of glucose to sorbitol. Sorbitol lens aldose reductase pseudogene Bos taurus
3 Preparations of bovine lens ALR2 exhibit biphasic kinetics with respect to glucose and various inhibitors including ICI 215918. Glucose lens aldose reductase pseudogene Bos taurus