Title : Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors.

Pub. Date : 2009 Mar

PMID : 19302153






5 Functional Relationships(s)
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1 The sedative and hypnotic agent 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol (THIP) is a GABA(A) receptor (GABA(A)R) agonist that preferentially activates delta-subunit-containing GABA(A)Rs (delta-GABA(A)Rs). 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
2 The sedative and hypnotic agent 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol (THIP) is a GABA(A) receptor (GABA(A)R) agonist that preferentially activates delta-subunit-containing GABA(A)Rs (delta-GABA(A)Rs). gaboxadol gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
3 The sedative and hypnotic agent 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol (THIP) is a GABA(A) receptor (GABA(A)R) agonist that preferentially activates delta-subunit-containing GABA(A)Rs (delta-GABA(A)Rs). gamma-Aminobutyric Acid gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
4 The sedative and hypnotic agent 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol (THIP) is a GABA(A) receptor (GABA(A)R) agonist that preferentially activates delta-subunit-containing GABA(A)Rs (delta-GABA(A)Rs). delta-gaba gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
5 Application of bicuculline to wild-type (WT) VB neurones revealed a GABA(A)R-mediated tonic current of 92 +/- 19 pA, which was greatly reduced (13 +/- 5 pA) for VB neurones of delta(0/0) mice. Bicuculline gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus