Title : Acute and chronic studies with the anticholinesterase Huperzine A: effect on central nervous system cholinergic parameters.

Pub. Date : 1991 Jul

PMID : 1922687






2 Functional Relationships(s)
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1 High affinity choline transport, choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were assessed in rats after acute and chronic administration of the AChE inhibitor Huperzine A. huperzine A acetylcholinesterase Rattus norvegicus
2 Thus, acute or chronic treatment with Huperzine A: did not alter ChAT; reduced high affinity choline transport in the hippocampus in a transient manner; and had a longer duration of action as an AChE inhibitor than physostigmine. huperzine A acetylcholinesterase Rattus norvegicus