Pub. Date : 1977 Feb
PMID : 191875
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hydrocortisone inhibition of the bradykinin activation of human synovial fibroblasts. | Hydrocortisone | kininogen 1 | Homo sapiens |
| 2 | Human synovial fibroblasts in culture respond to bradykinin with a 20-fold increment in intracellular cyclic AMP concentrations, however bradykinin does not directly activate adenylate cyclase activity in a particulate fraction derived from these cells. | Cyclic AMP | kininogen 1 | Homo sapiens |
| 3 | Bradykinin evokes a release of labeled arachidonic acid and prostaglandins E and F from synovial fibroblasts pre-labeled with 3H-arachidonic acid. | Arachidonic Acid | kininogen 1 | Homo sapiens |
| 4 | Bradykinin evokes a release of labeled arachidonic acid and prostaglandins E and F from synovial fibroblasts pre-labeled with 3H-arachidonic acid. | prostaglandins e and f | kininogen 1 | Homo sapiens |
| 5 | Bradykinin evokes a release of labeled arachidonic acid and prostaglandins E and F from synovial fibroblasts pre-labeled with 3H-arachidonic acid. | 3h-arachidonic acid | kininogen 1 | Homo sapiens |
| 6 | Hydrocortisone inhibits the bradykinin induced increment in cyclic AMP and the release of arachidonic acid and prostaglandins E and F from synovial fibroblasts. | Hydrocortisone | kininogen 1 | Homo sapiens |
| 7 | Hydrocortisone inhibits the bradykinin induced increment in cyclic AMP and the release of arachidonic acid and prostaglandins E and F from synovial fibroblasts. | Cyclic AMP | kininogen 1 | Homo sapiens |
| 8 | Hydrocortisone inhibits the bradykinin induced increment in cyclic AMP and the release of arachidonic acid and prostaglandins E and F from synovial fibroblasts. | Arachidonic Acid | kininogen 1 | Homo sapiens |
| 9 | Hydrocortisone inhibits the bradykinin induced increment in cyclic AMP and the release of arachidonic acid and prostaglandins E and F from synovial fibroblasts. | prostaglandins e and f | kininogen 1 | Homo sapiens |
| 10 | Indomethacin, which also inhibits the cyclic AMP response to bradykinin, has no effect on the release of arachidonic acid from synovial fibroblasts. | Indomethacin | kininogen 1 | Homo sapiens |
| 11 | Indomethacin, which also inhibits the cyclic AMP response to bradykinin, has no effect on the release of arachidonic acid from synovial fibroblasts. | Cyclic AMP | kininogen 1 | Homo sapiens |
| 12 | These studies support the hypothesis that bradykinin does not activate human synovial fibroblast adenylate cyclase, but presumably activates a phospholipase whose products in turn result in the synthesis of prostaglandins. | Prostaglandins | kininogen 1 | Homo sapiens |