Pub. Date : 2009 Mar
PMID : 19103749
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we demonstrate that bromodomains of Brd4 bind to acetylated lysine-310. | Lysine | bromodomain containing 4 | Homo sapiens |
| 2 | Brd4 enhances transcriptional activation of NF-kappaB and the expression of a subset of NF-kappaB-responsive inflammatory genes in an acetylated lysine-310-dependent manner. | Lysine | bromodomain containing 4 | Homo sapiens |
| 3 | Bromodomains of Brd4 and acetylated lysine-310 of RelA are both required for the mutual interaction and coactivation function of Brd4. | Lysine | bromodomain containing 4 | Homo sapiens |
| 4 | Our results identify Brd4 as a novel coactivator of NF-kappaB through specifically binding to acetylated lysine-310 of RelA. | Lysine | bromodomain containing 4 | Homo sapiens |