Title : Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis.

Pub. Date : 2008 Dec

PMID : 19021774






6 Functional Relationships(s)
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1 Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis. Chlorides angiotensin converting enzyme 2 Homo sapiens
2 Both ACE and ACE2 have catalytic activity that is chloride sensitive and is caused by the presence of the CL1 and CL2 chloride-binding sites in ACE and the CL1 site in ACE2. Chlorides angiotensin converting enzyme 2 Homo sapiens
3 Both ACE and ACE2 have catalytic activity that is chloride sensitive and is caused by the presence of the CL1 and CL2 chloride-binding sites in ACE and the CL1 site in ACE2. Chlorides angiotensin converting enzyme 2 Homo sapiens
4 The CL1 site residues Arg186, Trp279 and Arg489 of testicular ACE and the equivalent ACE2 residues Arg169, Trp271 and Lys481 were found to be critical to chloride sensitivity. Chlorides angiotensin converting enzyme 2 Homo sapiens
5 Inhibition of ACE2 was also found to be chloride sensitive, as for testicular ACE, with residues Arg169 and Arg514 of ACE2 identified as influencing the potency of the ACE2-specific inhibitor MLN-4760. Chlorides angiotensin converting enzyme 2 Homo sapiens
6 Consequently, important insights into the chloride sensitivity, substrate selectivity and inhibition of testicular ACE and ACE2 were elucidated. Chlorides angiotensin converting enzyme 2 Homo sapiens