Pub. Date : 2008 Oct
PMID : 18852132
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | During this interval, LAQ-824 induced early (4-8 h) increases in gamma-H2AX, which persisted (48 h) secondary to LAQ-824-mediated inhibition of DNA repair (e.g., down-regulation of Ku86 and Rad50, increased Ku70 acetylation, diminished Ku70 and Ku86 DNA-binding activity, and down-regulated DNA repair genes BRCA1, CHEK1, and RAD51). | LAQ824 | RAD50 double strand break repair protein | Homo sapiens |