Pub. Date : 2008 Oct 1
PMID : 18829552
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance. | Nucleosides | RAD50 double strand break repair protein | Homo sapiens |
| 2 | Using gamma-H2AX as a marker for changes in chromatin structure, we show that Mre11, Rad50, Nbs1, and phosphorylated ATM respond to nucleoside analogue-induced stalled replication forks by forming nuclear foci that colocalize with gamma-H2AX within 2 hours. | Nucleosides | RAD50 double strand break repair protein | Homo sapiens |
| 3 | Deficiencies in ATM, Mre11, or Rad50 led to a 2- to 5-fold increase in clonogenic sensitization to gemcitabine, whereas Nbs1 and H2AX deficiency did not affect reproductive growth. | gemcitabine | RAD50 double strand break repair protein | Homo sapiens |