Title : [The study on inhabiting endothelial cell aging by targeted silencing of p22phox].

Pub. Date : 2008 Sep

PMID : 18779176






1 Functional Relationships(s)
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1 The result of the present study suggested that siRNA could induce NAD(P)H oxidase subunit p22phox gene silence, Ang II could induce ECV-304 aging cultured in vitro, and the possible pathway of endothelial cell aging is that Ang II upregulates p22phox expression, and then enhances the cell ROS level. Reactive Oxygen Species cytochrome b-245 alpha chain Homo sapiens