Pub. Date : 2008 Dec 15
PMID : 18691157
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protective effect of paraoxonase-2 against endoplasmic reticulum stress-induced apoptosis is lost upon disturbance of calcium homoeostasis. | Calcium | paraoxonase 2 | Homo sapiens |
| 2 | Addressing the cytoprotective functions of PON2, we observed that PON2 overexpression provided significant resistance to ER-stress-induced caspase 3 activation when the ER stress was induced by interference with protein modification (by tunicamycin or dithiothreitol), but not when ER stress was induced by disturbance of Ca(2+) homoeostasis (by thapsigargin or A23187). | Tunicamycin | paraoxonase 2 | Homo sapiens |
| 3 | Addressing the cytoprotective functions of PON2, we observed that PON2 overexpression provided significant resistance to ER-stress-induced caspase 3 activation when the ER stress was induced by interference with protein modification (by tunicamycin or dithiothreitol), but not when ER stress was induced by disturbance of Ca(2+) homoeostasis (by thapsigargin or A23187). | Dithiothreitol | paraoxonase 2 | Homo sapiens |
| 4 | Addressing the cytoprotective functions of PON2, we observed that PON2 overexpression provided significant resistance to ER-stress-induced caspase 3 activation when the ER stress was induced by interference with protein modification (by tunicamycin or dithiothreitol), but not when ER stress was induced by disturbance of Ca(2+) homoeostasis (by thapsigargin or A23187). | Thapsigargin | paraoxonase 2 | Homo sapiens |
| 5 | Addressing the cytoprotective functions of PON2, we observed that PON2 overexpression provided significant resistance to ER-stress-induced caspase 3 activation when the ER stress was induced by interference with protein modification (by tunicamycin or dithiothreitol), but not when ER stress was induced by disturbance of Ca(2+) homoeostasis (by thapsigargin or A23187). | Calcimycin | paraoxonase 2 | Homo sapiens |
| 6 | However, only tunicamycin and dithiothreitol resulted in increased PON2 mRNA and protein levels. | Tunicamycin | paraoxonase 2 | Homo sapiens |
| 7 | However, only tunicamycin and dithiothreitol resulted in increased PON2 mRNA and protein levels. | Dithiothreitol | paraoxonase 2 | Homo sapiens |
| 8 | In addition, thapsigargin and A23187 also induced PON2 protein degradation by a Ca(2+)-dependent calpain-mediated mechanism. | Thapsigargin | paraoxonase 2 | Homo sapiens |
| 9 | In addition, thapsigargin and A23187 also induced PON2 protein degradation by a Ca(2+)-dependent calpain-mediated mechanism. | Calcimycin | paraoxonase 2 | Homo sapiens |