Pub. Date : 2008 Jun
PMID : 18567802
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The RNA exosome component hRrp6 is a target for 5-fluorouracil in human cells. | Fluorouracil | exosome component 10 | Homo sapiens |
| 2 | HeLa cells depleted of the inessential exosome component hRrp6, also called PM/Scl100, are significantly growth impaired relative to control cells after 5-FU administration. | Fluorouracil | exosome component 10 | Homo sapiens |
| 3 | HeLa cells depleted of the inessential exosome component hRrp6, also called PM/Scl100, are significantly growth impaired relative to control cells after 5-FU administration. | Fluorouracil | exosome component 10 | Homo sapiens |
| 4 | The selective stabilization of bona fide hRrp6 RNA substrates on 5-FU treatment suggests that this exosome component is specifically targeted. | Fluorouracil | exosome component 10 | Homo sapiens |
| 5 | Consistently, levels of hRrp6 substrates are increased in two 5-FU-sensitive cell lines. | Fluorouracil | exosome component 10 | Homo sapiens |