Title : Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice.

Pub. Date : 2008 Jul

PMID : 18551038






1 Functional Relationships(s)
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1 After MTX treatment, MTHFR-Tg mice exhibited the same decreases in hematological parameters as Mthfr-deficient mice, and significantly decreased thymidine synthesis (higher 2"-deoxyuridine 5"-triphosphate/2"-deoxythymidine 5"-triphosphate ratios) compared with wild-type mice, but they were protected from MTX-induced hyperhomocysteinemia. thymidine 5'-triphosphate methylenetetrahydrofolate reductase Mus musculus