Pub. Date : 1991 Nov
PMID : 1811554
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of gemfibrozil and ketoconazole on human apolipoprotein AI, B and E levels in two hepatoma cell lines, HepG2 and Hep3B. | Ketoconazole | apolipoprotein A1 | Homo sapiens |
| 2 | The hypothesis that the mechanism of action of gemfibrozil involved the cytochrome P-450 system was tested by using ketoconazole, a P-450 inhibitor, which blocks the formation of endogenous polar sterols. | Ketoconazole | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 3 | When the cells were treated with ketoconazole at a concentration of greater than or equal to 15 microM, the levels of apo AI, and apo B mRNAs decreased by 50% and 35%, respectively, compared to the basal level. | Ketoconazole | apolipoprotein A1 | Homo sapiens |