Title : Isoflurane is a potent modulator of extrasynaptic GABA(A) receptors in the thalamus.

Pub. Date : 2008 Mar

PMID : 18094320






3 Functional Relationships(s)
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1 These isoflurane-evoked currents reversed polarity close to the Cl(-) equilibrium potential and were totally blocked by the GABA(A)-R antagonist gabazine. Isoflurane gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
2 These isoflurane-evoked currents reversed polarity close to the Cl(-) equilibrium potential and were totally blocked by the GABA(A)-R antagonist gabazine. gabazine gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
3 In addition, isoflurane directly activated alpha(4)beta(2)delta GABA(A)-Rs expressed in human embryonic kidney 293 cells, and it was more potent at alpha(4)beta(2)delta than at alpha(1)beta(2)gamma(2) receptors (the presumptive extrasynaptic and synaptic GABA(A)-R subtypes in VB neurons). Isoflurane gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus