Title : Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling.

Pub. Date : 2008 Jan 1

PMID : 18071070






3 Functional Relationships(s)
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1 The absence of AC6 was associated with a 48% decay in beta-adrenergic receptor-stimulated cAMP production in cardiac myocytes (P=0.003) and reduced protein kinase A activity (P=0.015). Cyclic AMP adenylate cyclase 6 Mus musculus
2 CONCLUSIONS: The combination of impaired cardiac cAMP generation and calcium handling that result from AC6 deletion underlies abnormalities in left ventricular function. Cyclic AMP adenylate cyclase 6 Mus musculus
3 CONCLUSIONS: The combination of impaired cardiac cAMP generation and calcium handling that result from AC6 deletion underlies abnormalities in left ventricular function. Calcium adenylate cyclase 6 Mus musculus