Title : Biological role, protein expression, subcellular localization, and oxidative stress response of paraoxonase 2 in the intestine of humans and rats.

Pub. Date : 2007 Dec

PMID : 17916643






7 Functional Relationships(s)
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1 Iron ascorbate-mediated lipid peroxidation induced a marked decrease in PON2 expression in intestinal specimens coincidental to an abundant rise in malondialdehyde (MDA). iron-ascorbate paraoxonase 2 Homo sapiens
2 On the other hand, preincubation with potent antioxidants, such as butylated hydroxytoluene, Trolox, and N-acetylcysteine, prevented iron-ascorbate-generating PON2 reduction in parallel with MDA suppression. Butylated Hydroxytoluene paraoxonase 2 Homo sapiens
3 On the other hand, preincubation with potent antioxidants, such as butylated hydroxytoluene, Trolox, and N-acetylcysteine, prevented iron-ascorbate-generating PON2 reduction in parallel with MDA suppression. 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid paraoxonase 2 Homo sapiens
4 On the other hand, preincubation with potent antioxidants, such as butylated hydroxytoluene, Trolox, and N-acetylcysteine, prevented iron-ascorbate-generating PON2 reduction in parallel with MDA suppression. Acetylcysteine paraoxonase 2 Homo sapiens
5 On the other hand, preincubation with potent antioxidants, such as butylated hydroxytoluene, Trolox, and N-acetylcysteine, prevented iron-ascorbate-generating PON2 reduction in parallel with MDA suppression. iron-ascorbate paraoxonase 2 Homo sapiens
6 Finally, the preincubation of permeabilized Caco-2 cells with purified PON2 led to a protection against iron-ascorbate-induced lipid peroxidation. Iron paraoxonase 2 Homo sapiens
7 Finally, the preincubation of permeabilized Caco-2 cells with purified PON2 led to a protection against iron-ascorbate-induced lipid peroxidation. Ascorbic Acid paraoxonase 2 Homo sapiens