Title : Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression.

Pub. Date : 2008 Jan

PMID : 17906677






2 Functional Relationships(s)
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1 KEY RESULTS: Gene transfer of ACE2 suppressed the expression of p22phox and MIF induced by angiotensin (Ang) II and Ang IV, accompanied by a decreased level of malondialdehyde in cells. Malondialdehyde angiotensin converting enzyme 2 Homo sapiens
2 In addition, Ang II diminished insulin-stimulated phosphorylation of Akt (at Ser(473)) and eNOS (at Ser(1177)) and NO generation, effects which were reversed by ACE2 gene transfer and anti-MIF treatment in endothelial cells. Serine angiotensin converting enzyme 2 Homo sapiens