Pub. Date : 2007 Nov 9
PMID : 17875639
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. | Ethanol | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 2 | Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. | Benzodiazepines | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 3 | We used this mutant and PKCepsilon(-/-) mice to determine that PKCepsilon phosphorylates gamma2 subunits at serine 327 and that reduced phosphorylation of this site enhances the actions of ethanol and benzodiazepines at alpha1beta2gamma2 receptors, which is the most abundant GABA(A) receptor subtype in the brain. | Serine | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 4 | We used this mutant and PKCepsilon(-/-) mice to determine that PKCepsilon phosphorylates gamma2 subunits at serine 327 and that reduced phosphorylation of this site enhances the actions of ethanol and benzodiazepines at alpha1beta2gamma2 receptors, which is the most abundant GABA(A) receptor subtype in the brain. | Ethanol | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 5 | We used this mutant and PKCepsilon(-/-) mice to determine that PKCepsilon phosphorylates gamma2 subunits at serine 327 and that reduced phosphorylation of this site enhances the actions of ethanol and benzodiazepines at alpha1beta2gamma2 receptors, which is the most abundant GABA(A) receptor subtype in the brain. | Benzodiazepines | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 6 | We used this mutant and PKCepsilon(-/-) mice to determine that PKCepsilon phosphorylates gamma2 subunits at serine 327 and that reduced phosphorylation of this site enhances the actions of ethanol and benzodiazepines at alpha1beta2gamma2 receptors, which is the most abundant GABA(A) receptor subtype in the brain. | gamma-Aminobutyric Acid | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 7 | Our findings indicate that PKCepsilon phosphorylation of gamma2 regulates the response of GABA(A) receptors to specific allosteric modulators, and, in particular, PKCepsilon inhibition renders these receptors sensitive to low intoxicating concentrations of ethanol. | Ethanol | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |