Title : Effects of dexamethasone exposure on rat metanephric development: in vitro and in vivo studies.

Pub. Date : 2007 Aug

PMID : 17537984






3 Functional Relationships(s)
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Protein Name
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1 DEX exposure in vitro decreased expression of glial cell line-derived neurotrophic factor (GDNF) and increased expression of bone morphogenetic protein-4 (BMP-4) and transforming growth factor-beta1 (TGF-beta1). Dexamethasone bone morphogenetic protein 4 Rattus norvegicus
2 DEX exposure in vitro decreased expression of glial cell line-derived neurotrophic factor (GDNF) and increased expression of bone morphogenetic protein-4 (BMP-4) and transforming growth factor-beta1 (TGF-beta1). Dexamethasone bone morphogenetic protein 4 Rattus norvegicus
3 However, in kidneys collected at E20.5 after in vivo exposure for 2 days, GDNF expression was increased and BMP-4 and TGF-beta1 expression decreased suggesting a biphasic response in gene expression to DEX exposure. Dexamethasone bone morphogenetic protein 4 Rattus norvegicus