Pub. Date : 1992 Mar
PMID : 1735464
16 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cell growth inhibition by prostaglandin A2 results in elevated expression of gadd153 mRNA. | prostaglandin A2 | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | Treatment of Hela cells with prostaglandin A2 (PGA2) resulted in a marked inhibition of cell proliferation which was associated with a significant induction of gadd153 mRNA, a member of a novel class of genes associated with growth arrest and DNA damage. | prostaglandin A2 | DNA damage inducible transcript 3 | Homo sapiens |
| 3 | Treatment of Hela cells with prostaglandin A2 (PGA2) resulted in a marked inhibition of cell proliferation which was associated with a significant induction of gadd153 mRNA, a member of a novel class of genes associated with growth arrest and DNA damage. | prostaglandin A2 | DNA damage inducible transcript 3 | Homo sapiens |
| 4 | Induction of gadd153 mRNA was specific to prostaglandins capable of arresting cell growth and was dose-dependent with the maximum effect seen at 36 microM PGA2. | Prostaglandins | DNA damage inducible transcript 3 | Homo sapiens |
| 5 | Induction of gadd153 mRNA was specific to prostaglandins capable of arresting cell growth and was dose-dependent with the maximum effect seen at 36 microM PGA2. | prostaglandin A2 | DNA damage inducible transcript 3 | Homo sapiens |
| 6 | Induction was rapid, occurring within 2-4 h and reaching a maximum by 8 h. These effects were reversible as removal of PGA2 resulted in a rapid decline in gadd153 mRNA levels coincident with resumption of cell growth. | prostaglandin A2 | DNA damage inducible transcript 3 | Homo sapiens |
| 7 | PGA2 induction of gadd153 mRNA was completely prevented by the presence of actinomycin D at a concentration sufficient to block transcription and was partially inhibited (50%) by the protein synthesis inhibitor cycloheximide. | prostaglandin A2 | DNA damage inducible transcript 3 | Homo sapiens |
| 8 | PGA2 induction of gadd153 mRNA was completely prevented by the presence of actinomycin D at a concentration sufficient to block transcription and was partially inhibited (50%) by the protein synthesis inhibitor cycloheximide. | Dactinomycin | DNA damage inducible transcript 3 | Homo sapiens |
| 9 | PGA2 induction of gadd153 mRNA was completely prevented by the presence of actinomycin D at a concentration sufficient to block transcription and was partially inhibited (50%) by the protein synthesis inhibitor cycloheximide. | Cycloheximide | DNA damage inducible transcript 3 | Homo sapiens |
| 10 | The presence of the protein kinase inhibitor 2-aminopurine decreased the PGA2 induction of gadd153 mRNA by greater than 90%, suggesting that cellular kinases play a role in the induction of gadd153 by PGA2. | 2-Aminopurine | DNA damage inducible transcript 3 | Homo sapiens |
| 11 | The presence of the protein kinase inhibitor 2-aminopurine decreased the PGA2 induction of gadd153 mRNA by greater than 90%, suggesting that cellular kinases play a role in the induction of gadd153 by PGA2. | 2-Aminopurine | DNA damage inducible transcript 3 | Homo sapiens |
| 12 | The presence of the protein kinase inhibitor 2-aminopurine decreased the PGA2 induction of gadd153 mRNA by greater than 90%, suggesting that cellular kinases play a role in the induction of gadd153 by PGA2. | prostaglandin A2 | DNA damage inducible transcript 3 | Homo sapiens |
| 13 | The presence of the protein kinase inhibitor 2-aminopurine decreased the PGA2 induction of gadd153 mRNA by greater than 90%, suggesting that cellular kinases play a role in the induction of gadd153 by PGA2. | prostaglandin A2 | DNA damage inducible transcript 3 | Homo sapiens |
| 14 | The presence of the protein kinase inhibitor 2-aminopurine decreased the PGA2 induction of gadd153 mRNA by greater than 90%, suggesting that cellular kinases play a role in the induction of gadd153 by PGA2. | prostaglandin A2 | DNA damage inducible transcript 3 | Homo sapiens |
| 15 | The presence of the protein kinase inhibitor 2-aminopurine decreased the PGA2 induction of gadd153 mRNA by greater than 90%, suggesting that cellular kinases play a role in the induction of gadd153 by PGA2. | prostaglandin A2 | DNA damage inducible transcript 3 | Homo sapiens |
| 16 | Thus PGA2-mediated growth arrest provides a useful model to further define the role of gadd153 in the negative control of cell growth. | prostaglandin A2 | DNA damage inducible transcript 3 | Homo sapiens |