Pub. Date : 2007 Feb
PMID : 17259375
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Added to isolated mouse islets in the presence of 0.5 mmol/l glucose, gamma-aminobutyric acid (GABA) inhibited glucagon release to a similar extent (46%) as 10 mmol/l glucose (55%), and the selective GABA(A) receptor (GABA(A)R) antagonist SR95531 substantially reversed the inhibition of glucagon release by high glucose. | gamma-Aminobutyric Acid | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 2 | Added to isolated mouse islets in the presence of 0.5 mmol/l glucose, gamma-aminobutyric acid (GABA) inhibited glucagon release to a similar extent (46%) as 10 mmol/l glucose (55%), and the selective GABA(A) receptor (GABA(A)R) antagonist SR95531 substantially reversed the inhibition of glucagon release by high glucose. | gamma-Aminobutyric Acid | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 3 | Added to isolated mouse islets in the presence of 0.5 mmol/l glucose, gamma-aminobutyric acid (GABA) inhibited glucagon release to a similar extent (46%) as 10 mmol/l glucose (55%), and the selective GABA(A) receptor (GABA(A)R) antagonist SR95531 substantially reversed the inhibition of glucagon release by high glucose. | gamma-Aminobutyric Acid | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 4 | Added to isolated mouse islets in the presence of 0.5 mmol/l glucose, gamma-aminobutyric acid (GABA) inhibited glucagon release to a similar extent (46%) as 10 mmol/l glucose (55%), and the selective GABA(A) receptor (GABA(A)R) antagonist SR95531 substantially reversed the inhibition of glucagon release by high glucose. | gamma-Aminobutyric Acid | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 5 | Glucose dose-dependently increased GABA(A)R expression in both islets and alphaTC1-9 cells such that mRNA levels at 16 mmol/l glucose were approximately 3.0-fold (alpha4), 2.0-fold (beta3), or 1.5-fold (gamma2) higher than at basal glucose concentrations (2.5 or 1.0 mmol/l, respectively). | Glucose | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 6 | Glucose dose-dependently increased GABA(A)R expression in both islets and alphaTC1-9 cells such that mRNA levels at 16 mmol/l glucose were approximately 3.0-fold (alpha4), 2.0-fold (beta3), or 1.5-fold (gamma2) higher than at basal glucose concentrations (2.5 or 1.0 mmol/l, respectively). | Glucose | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 7 | Glucose dose-dependently increased GABA(A)R expression in both islets and alphaTC1-9 cells such that mRNA levels at 16 mmol/l glucose were approximately 3.0-fold (alpha4), 2.0-fold (beta3), or 1.5-fold (gamma2) higher than at basal glucose concentrations (2.5 or 1.0 mmol/l, respectively). | Glucose | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 8 | We conclude that 1) release of GABA from neighboring beta-cells contributes substantially to the acute inhibition of glucagon secretion from mouse islets by glucose and 2) that changes in GABA(A)R expression, mediated by changes in intracellular free Ca(2+) concentration, may modulate this response in the long term. | gamma-Aminobutyric Acid | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |