Title : Protective effects of human recombinant MnSOD in adjuvant arthritis and bleomycin-induced lung fibrosis.

Pub. Date : 1991

PMID : 1725166






4 Functional Relationships(s)
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1 Protective effects of human recombinant MnSOD in adjuvant arthritis and bleomycin-induced lung fibrosis. Bleomycin superoxide dismutase 2 Homo sapiens
2 We have previously shown that human recombinant methionyl manganese superoxide dismutase (MnSOD) is more efficient than CuZnSOD as an anti-inflammatory agent in a model of acute inflammation (Carrageenan-induced paw edema). Carrageenan superoxide dismutase 2 Homo sapiens
3 We have previously shown that human recombinant methionyl manganese superoxide dismutase (MnSOD) is more efficient than CuZnSOD as an anti-inflammatory agent in a model of acute inflammation (Carrageenan-induced paw edema). Carrageenan superoxide dismutase 2 Homo sapiens
4 MnSOD (50 mg/kg, s.c.), administered 2 h before and then 2 and 4 days after bleomycin, markedly inhibited lung fibrosis, as evident from lung weight and collagen content measured by the 3rd week. Bleomycin superoxide dismutase 2 Homo sapiens