Pub. Date : 2006 Oct
PMID : 16984258
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Platelet-activating factor (PAF) is a group of phosphocholines with various biological effects mediated by the PAF receptor (PAF-R). | Phosphorylcholine | platelet activating factor receptor | Homo sapiens |
| 2 | Platelet-activating factor (PAF) is a group of phosphocholines with various biological effects mediated by the PAF receptor (PAF-R). | Phosphorylcholine | platelet activating factor receptor | Homo sapiens |
| 3 | Activation of the epidermal PAF-R induces the expression of inflammatory mediators, including cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)). | Dinoprostone | platelet activating factor receptor | Homo sapiens |
| 4 | Activation of the epidermal PAF-R induces the expression of inflammatory mediators, including cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)). | Prostaglandins E | platelet activating factor receptor | Homo sapiens |
| 5 | The present study was designed to investigate whether PAF-R activation could induce the expression of COX-2 and production of PGE(2), as well as secretion of the inflammatory cytokine, interleukin-8 (IL-8), in the immortalized sebaceous gland cell line SZ95. | Dinoprostone | platelet activating factor receptor | Homo sapiens |
| 6 | Finally, it was demonstrated that the production of PGE(2), induced by PAF-R activation and mediated by COX-2 expression, was blocked following PAF-R antagonism in SZ95 sebocytes. | Prostaglandins E | platelet activating factor receptor | Homo sapiens |
| 7 | Finally, it was demonstrated that the production of PGE(2), induced by PAF-R activation and mediated by COX-2 expression, was blocked following PAF-R antagonism in SZ95 sebocytes. | Prostaglandins E | platelet activating factor receptor | Homo sapiens |