Pub. Date : 2006 Dec
PMID : 16972264
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rap1 and p38 MAPK mediate 8-chloro-cAMP-induced growth inhibition in mouse fibroblast DT cells. | 8-chloro-cyclic adenosine monophosphate | RAS-related protein 1a | Mus musculus |
| 2 | Rap1 and p38 MAPK mediate 8-chloro-cAMP-induced growth inhibition in mouse fibroblast DT cells. | 8-chloro-cyclic adenosine monophosphate | mitogen-activated protein kinase 14 | Mus musculus |
| 3 | Previously, we reported that 8-Cl-cAMP and its metabolite 8-Cl-adenosine induce growth inhibition and apoptosis through p38 mitogen-activated protein kinase (MAPK) activation. | 8-chloro-cyclic adenosine monophosphate | mitogen-activated protein kinase 14 | Mus musculus |
| 4 | To further investigate the signal mechanisms that regulate the cellular effects of 8-Cl-cAMP, we focused on a small GTPase Rap1 that is known to be involved in growth inhibition and reverse-transformation. | 8-chloro-cyclic adenosine monophosphate | RAS-related protein 1a | Mus musculus |
| 5 | 8-Cl-cAMP and 8-Cl-adenosine could increase Rap1 activity, which was blocked by ABT702-an adenosine kinase inhibitor. | 8-chloro-cyclic adenosine monophosphate | RAS-related protein 1a | Mus musculus |
| 6 | This suggests that 8-Cl-cAMP-induced Rap1 activation is also dependent on the metabolic degradation of 8-Cl-cAMP. | 8-chloro-cyclic adenosine monophosphate | RAS-related protein 1a | Mus musculus |
| 7 | This suggests that 8-Cl-cAMP-induced Rap1 activation is also dependent on the metabolic degradation of 8-Cl-cAMP. | 8-chloro-cyclic adenosine monophosphate | RAS-related protein 1a | Mus musculus |
| 8 | Overexpression of a constitutively active mutant form of Rap1 (Rap1V12) attenuated cellular growth and soft-agar colony formation, which was basically the same effect as that observed with the 8-Cl-cAMP treatment. | 8-chloro-cyclic adenosine monophosphate | RAS-related protein 1a | Mus musculus |
| 9 | However, 8-Cl-cAMP-induced Rap1 activation was not diminished by SB203580, a p38 MAPK inhibitor, suggesting that Rap1 activation might act upstream of p38 MAPK activation during 8-Cl-cAMP-induced growth inhibition. | 8-chloro-cyclic adenosine monophosphate | RAS-related protein 1a | Mus musculus |
| 10 | However, 8-Cl-cAMP-induced Rap1 activation was not diminished by SB203580, a p38 MAPK inhibitor, suggesting that Rap1 activation might act upstream of p38 MAPK activation during 8-Cl-cAMP-induced growth inhibition. | 8-chloro-cyclic adenosine monophosphate | RAS-related protein 1a | Mus musculus |
| 11 | However, 8-Cl-cAMP-induced Rap1 activation was not diminished by SB203580, a p38 MAPK inhibitor, suggesting that Rap1 activation might act upstream of p38 MAPK activation during 8-Cl-cAMP-induced growth inhibition. | 8-chloro-cyclic adenosine monophosphate | mitogen-activated protein kinase 14 | Mus musculus |
| 12 | However, 8-Cl-cAMP-induced Rap1 activation was not diminished by SB203580, a p38 MAPK inhibitor, suggesting that Rap1 activation might act upstream of p38 MAPK activation during 8-Cl-cAMP-induced growth inhibition. | 8-chloro-cyclic adenosine monophosphate | RAS-related protein 1a | Mus musculus |
| 13 | However, 8-Cl-cAMP-induced Rap1 activation was not diminished by SB203580, a p38 MAPK inhibitor, suggesting that Rap1 activation might act upstream of p38 MAPK activation during 8-Cl-cAMP-induced growth inhibition. | 8-chloro-cyclic adenosine monophosphate | mitogen-activated protein kinase 14 | Mus musculus |
| 14 | However, 8-Cl-cAMP-induced Rap1 activation was not diminished by SB203580, a p38 MAPK inhibitor, suggesting that Rap1 activation might act upstream of p38 MAPK activation during 8-Cl-cAMP-induced growth inhibition. | 8-chloro-cyclic adenosine monophosphate | RAS-related protein 1a | Mus musculus |
| 15 | However, 8-Cl-cAMP-induced Rap1 activation was not diminished by SB203580, a p38 MAPK inhibitor, suggesting that Rap1 activation might act upstream of p38 MAPK activation during 8-Cl-cAMP-induced growth inhibition. | 8-chloro-cyclic adenosine monophosphate | mitogen-activated protein kinase 14 | Mus musculus |