Title : Rap1 and p38 MAPK mediate 8-chloro-cAMP-induced growth inhibition in mouse fibroblast DT cells.

Pub. Date : 2006 Dec

PMID : 16972264






2 Functional Relationships(s)
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1 Previously, we reported that 8-Cl-cAMP and its metabolite 8-Cl-adenosine induce growth inhibition and apoptosis through p38 mitogen-activated protein kinase (MAPK) activation. 8-chloroadenosine mitogen-activated protein kinase 14 Mus musculus
2 8-Cl-cAMP and 8-Cl-adenosine could increase Rap1 activity, which was blocked by ABT702-an adenosine kinase inhibitor. 8-chloroadenosine RAS-related protein 1a Mus musculus