Pub. Date : 1990 Jan 15
PMID : 1688548
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 8-Chloro-cAMP inhibits transforming growth factor alpha transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation. | 8-chloro-cyclic adenosine monophosphate | transforming growth factor alpha | Mus musculus |
| 2 | 8-Chloro-cAMP inhibits transforming growth factor alpha transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation. | 8-chloro-cyclic adenosine monophosphate | transforming growth factor alpha | Mus musculus |
| 3 | Such selective modulation of protein kinase isozyme regulatory subunits was also found in the 8-Cl-cAMP-induced inhibition of both transformation and transforming growth factor alpha (TGF alpha) production in Ki-ras-transformed rat kidney fibroblasts (Tortora, G., Ciardiello, F., Ally, S., Clair, T., Salomon, D. S., and Cho-Chung, Y. S. (1989) FEBS Lett. | 8-chloro-cyclic adenosine monophosphate | transforming growth factor alpha | Rattus norvegicus |
| 4 | Such selective modulation of protein kinase isozyme regulatory subunits was also found in the 8-Cl-cAMP-induced inhibition of both transformation and transforming growth factor alpha (TGF alpha) production in Ki-ras-transformed rat kidney fibroblasts (Tortora, G., Ciardiello, F., Ally, S., Clair, T., Salomon, D. S., and Cho-Chung, Y. S. (1989) FEBS Lett. | 8-chloro-cyclic adenosine monophosphate | transforming growth factor alpha | Rattus norvegicus |
| 5 | In this work, we have demonstrated that 8-Cl-cAMP antagonizes the TGF alpha effect in TGF alpha-transformed mouse mammary epithelial cells (NOG-8TFC17) at the level of gene expression for cAMP receptor protein isoforms, RI and RII (the regulatory subunits of protein kinase isozymes). | 8-chloro-cyclic adenosine monophosphate | transforming growth factor alpha | Mus musculus |
| 6 | In this work, we have demonstrated that 8-Cl-cAMP antagonizes the TGF alpha effect in TGF alpha-transformed mouse mammary epithelial cells (NOG-8TFC17) at the level of gene expression for cAMP receptor protein isoforms, RI and RII (the regulatory subunits of protein kinase isozymes). | 8-chloro-cyclic adenosine monophosphate | transforming growth factor alpha | Mus musculus |
| 7 | In this work, we have demonstrated that 8-Cl-cAMP antagonizes the TGF alpha effect in TGF alpha-transformed mouse mammary epithelial cells (NOG-8TFC17) at the level of gene expression for cAMP receptor protein isoforms, RI and RII (the regulatory subunits of protein kinase isozymes). | 8-chloro-cyclic adenosine monophosphate | transforming growth factor alpha | Mus musculus |
| 8 | In this work, we have demonstrated that 8-Cl-cAMP antagonizes the TGF alpha effect in TGF alpha-transformed mouse mammary epithelial cells (NOG-8TFC17) at the level of gene expression for cAMP receptor protein isoforms, RI and RII (the regulatory subunits of protein kinase isozymes). | 8-chloro-cyclic adenosine monophosphate | transforming growth factor alpha | Mus musculus |
| 9 | 8-Cl-cAMP, which induced growth inhibition and phenotypic reversion in NOG-8TFC17 cells, caused an inverse change in the mRNA patterns of the cAMP receptor proteins; RI alpha cAMP receptor mRNA sharply decreased to levels comparable with that of the nontransformed NOG-8 cells, whereas RII beta mRNA increased to a level even greater than that in the NOG-8 cells. | 8-chloro-cyclic adenosine monophosphate | protein kinase, cAMP dependent regulatory, type II beta | Mus musculus |
| 10 | In addition, 8-Cl-cAMP brought about a reduction in both TGF alpha mRNA and protein levels. | 8-chloro-cyclic adenosine monophosphate | transforming growth factor alpha | Mus musculus |
| 11 | Thus, the antagonistic effect of 8-Cl-cAMP toward TGF alpha-induced transformation involves modulation of the expression of a specific set of cellular genes. | 8-chloro-cyclic adenosine monophosphate | transforming growth factor alpha | Mus musculus |