Title : Identification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor.

Pub. Date : 2006 Jun 20

PMID : 16510163






2 Functional Relationships(s)
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Protein Name
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1 Alanine scanning mutagenesis analysis was performed to identify determinants on ACE2 critical for SARS-CoV infection. Alanine angiotensin converting enzyme 2 Homo sapiens
2 One peptide comprised of two discontinuous segments of ACE2 (a.a. 22-44 and 351-357) artificially linked together by glycine, exhibited a potent antiviral activity with IC50 of about 0.1 microM. Glycine angiotensin converting enzyme 2 Homo sapiens