Pub. Date : 2006 Feb
PMID : 16339075
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that Brd4 was rapidly released from chromosomes upon treatment with antimicrotubule drugs, including the reversible agent nocodazole. | Nocodazole | bromodomain containing 4 | Homo sapiens |
| 2 | Yet, when nocodazole was withdrawn, Brd4 was reloaded onto chromosomes, and cells proceeded to complete cell division. | Nocodazole | bromodomain containing 4 | Homo sapiens |
| 3 | Consequently, Brd4+/- cells were impaired in their ability to recover from nocodazole-induced mitotic arrest: a large fraction of +/- cells failed to reach anaphase after drug withdrawal, and those that entered anaphase showed an increased frequency of abnormal chromosomal segregation. | Nocodazole | bromodomain containing 4 | Homo sapiens |
| 4 | The reloading defect observed in Brd4+/- cells coincided with selective hypoacetylation of lysine residues on H3 and H4. | Lysine | bromodomain containing 4 | Homo sapiens |
| 5 | The histone deacetylase inhibitor trichostatin A increased global histone acetylation and perturbed nocodazole-induced Brd4 unloading. | trichostatin A | bromodomain containing 4 | Homo sapiens |
| 6 | The histone deacetylase inhibitor trichostatin A increased global histone acetylation and perturbed nocodazole-induced Brd4 unloading. | Nocodazole | bromodomain containing 4 | Homo sapiens |