Pub. Date : 2006 Apr
PMID : 16019190
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NOX4 as an oxygen sensor to regulate TASK-1 activity. | Oxygen | NADPH oxidase 4 | Homo sapiens |
| 2 | In the present study, we propose that the NADPH oxidase NOX4 functions as an oxygen-sensing partner and that it modulates the oxygen sensitivity of TASK-1. | Oxygen | NADPH oxidase 4 | Homo sapiens |
| 3 | In the present study, we propose that the NADPH oxidase NOX4 functions as an oxygen-sensing partner and that it modulates the oxygen sensitivity of TASK-1. | Oxygen | NADPH oxidase 4 | Homo sapiens |
| 4 | In HEK293 cells expressing NOX4 endogenously, the activity of expressed TASK-1 was moderately inhibited by hypoxia, and this oxygen response was significantly augmented by NOX4. | Oxygen | NADPH oxidase 4 | Homo sapiens |
| 5 | In HEK293 cells expressing NOX4 endogenously, the activity of expressed TASK-1 was moderately inhibited by hypoxia, and this oxygen response was significantly augmented by NOX4. | Oxygen | NADPH oxidase 4 | Homo sapiens |
| 6 | Moreover, the oxygen sensitivity of TASK-1 was abolished by NOX4 siRNA and NADPH oxidase inhibitors. | Oxygen | NADPH oxidase 4 | Homo sapiens |
| 7 | These results suggest a novel function for NOX4 in the oxygen-dependent regulation of TASK-1 activity. | Oxygen | NADPH oxidase 4 | Homo sapiens |