Pub. Date : 1992 Jan
PMID : 1593845
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Elevated glucose stimulates TGF-beta gene expression and bioactivity in proximal tubule. | Glucose | transforming growth factor, beta 1 | Mus musculus |
| 2 | Because transforming growth factor-beta (TGF-beta) inhibits cell proliferation in most epithelial cell lines, we hypothesized that the inhibitory effect of high glucose levels on cell proliferation may be mediated by TGF-beta. | Glucose | transforming growth factor, beta 1 | Mus musculus |
| 3 | Because transforming growth factor-beta (TGF-beta) inhibits cell proliferation in most epithelial cell lines, we hypothesized that the inhibitory effect of high glucose levels on cell proliferation may be mediated by TGF-beta. | Glucose | transforming growth factor, beta 1 | Mus musculus |
| 4 | The present studies were performed to test the hypothesis that TGF-beta is an autocrine cytokine whose activity can be modulated by ambient glucose. | Glucose | transforming growth factor, beta 1 | Mus musculus |
| 5 | Exogenous TGF-beta inhibited [3H]-thymidine incorporation in a dose-dependent fashion and with high affinity (picomolar range), but with slightly lower potency in high versus normal glucose media. | Tritium | transforming growth factor, beta 1 | Mus musculus |
| 6 | Exogenous TGF-beta inhibited [3H]-thymidine incorporation in a dose-dependent fashion and with high affinity (picomolar range), but with slightly lower potency in high versus normal glucose media. | Thymidine | transforming growth factor, beta 1 | Mus musculus |
| 7 | Exogenous TGF-beta inhibited [3H]-thymidine incorporation in a dose-dependent fashion and with high affinity (picomolar range), but with slightly lower potency in high versus normal glucose media. | Glucose | transforming growth factor, beta 1 | Mus musculus |
| 8 | Northern analysis of mRNA demonstrated that proximal tubule cells constitutively express TGF-beta 1 transcripts, and that the steady state level of TGF-beta 1 mRNA was, on average, 63% higher in the cells grown for 48 hours in high versus normal glucose media. | Glucose | transforming growth factor, beta 1 | Mus musculus |
| 9 | Furthermore, the conditioned media of cells exposed to 450 mg/dl glucose exhibited endogenous TGF-beta bioactivity as measured by inhibition of cell proliferation. | Glucose | transforming growth factor, beta 1 | Mus musculus |
| 10 | The addition of a rabbit antiporcine TGF-beta neutralizing antibody significantly increased basal thymidine incorporation in high glucose media to levels approaching those of cells grown in normal glucose media. | Thymidine | transforming growth factor, beta 1 | Mus musculus |
| 11 | The addition of a rabbit antiporcine TGF-beta neutralizing antibody significantly increased basal thymidine incorporation in high glucose media to levels approaching those of cells grown in normal glucose media. | Glucose | transforming growth factor, beta 1 | Mus musculus |
| 12 | The addition of a rabbit antiporcine TGF-beta neutralizing antibody significantly increased basal thymidine incorporation in high glucose media to levels approaching those of cells grown in normal glucose media. | Glucose | transforming growth factor, beta 1 | Mus musculus |