Title : Aprepitant inhibits cyclophosphamide bioactivation and thiotepa metabolism.

Pub. Date : 2005 Oct

PMID : 15838656






2 Functional Relationships(s)
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1 CONCLUSION: Aprepitant inhibited both cyclophosphamide and thiotepa metabolism, most probably due to inhibition of the CYP 3A4 and/or 2B6 isoenzymes. Thiotepa cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 CONCLUSION: Aprepitant inhibited both cyclophosphamide and thiotepa metabolism, most probably due to inhibition of the CYP 3A4 and/or 2B6 isoenzymes. Thiotepa olfactory receptor family 2 subfamily B member 6 Homo sapiens