Pub. Date : 2005 Feb 1
PMID : 15652242
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of human CYP2B6 by N,N",N""-triethylenethiophosphoramide is irreversible and mechanism-based. | Thiotepa | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | Previous studies demonstrated partial inhibition by thioTEPA of the cytochrome P4502B6 (CYP2B6)-catalyzed 4-hydroxylation of cyclophosphamide, which is required for its bioactivation. | Thiotepa | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | The aim of our study was to investigate the detailed mechanism of CYP2B6 inhibition by thioTEPA. | Thiotepa | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | ThioTEPA was found to inhibit CYP2B6 activity in a time- and concentration-dependent manner. | Thiotepa | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |