Pub. Date : 2005 Mar
PMID : 15611481
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4. | Morphine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 2 | Modulation of UDP-glucuronosyltransferase 2B7 (UGT2B7)-catalyzed morphine glucuronidation by cytochrome P450 (P450) was studied. | Morphine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 3 | The effects of P450 isozymes on the kinetic parameters of UGT2B7-catalyzed glucuronidation of the morphine 3-hydroxyl group were examined by simultaneous expression of UGT2B7 and either CYP3A4, -1A2, or -2C9 in COS-1 cells. | Morphine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 4 | In contrast, the formation of morphine-3-glucuronide by detergent-treated microsomes from COS-1 cells expressing UGT2B7 was reduced by CYP3A4, whereas the formation of the 6-glucuronide was enhanced. | morphine-3-glucuronide | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 5 | In contrast, the formation of morphine-3-glucuronide by detergent-treated microsomes from COS-1 cells expressing UGT2B7 was reduced by CYP3A4, whereas the formation of the 6-glucuronide was enhanced. | carbonyl sulfide | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 6 | In contrast, the formation of morphine-3-glucuronide by detergent-treated microsomes from COS-1 cells expressing UGT2B7 was reduced by CYP3A4, whereas the formation of the 6-glucuronide was enhanced. | 6-glucuronide | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 7 | These results strongly suggest that 1) the glucuronidation activity of UGT2B7 toward morphine is specifically modulated by interaction with CYP3A4 in microsomal membranes and that 2) CYP3A4 alters UGT2B7 regioselectivity so that the ratio of morphine activation/detoxication is increased. | Morphine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 8 | These results strongly suggest that 1) the glucuronidation activity of UGT2B7 toward morphine is specifically modulated by interaction with CYP3A4 in microsomal membranes and that 2) CYP3A4 alters UGT2B7 regioselectivity so that the ratio of morphine activation/detoxication is increased. | Morphine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 9 | These results strongly suggest that 1) the glucuronidation activity of UGT2B7 toward morphine is specifically modulated by interaction with CYP3A4 in microsomal membranes and that 2) CYP3A4 alters UGT2B7 regioselectivity so that the ratio of morphine activation/detoxication is increased. | Morphine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |