Pub. Date : 2004 Oct 8
PMID : 15351734
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity. | Gentamicins | calreticulin | Bos taurus |
| 2 | One of the gentamicin-binding proteins was identified as calreticulin (CRT) by N-terminal amino acid sequence analysis. | Gentamicins | calreticulin | Bos taurus |
| 3 | One of the gentamicin-binding proteins was identified as calreticulin (CRT) by N-terminal amino acid sequence analysis. | Gentamicins | calreticulin | Bos taurus |
| 4 | Interestingly, gentamicin inhibited the chaperone and oxidative refolding activities of CRT when N-glycosylated substrates such as alpha1-antitrypsin and alpha-mannosidase were used as substrates, but it did not inhibit the chaperone activity of CRT when unglycosylated citrate synthase was used. | Gentamicins | calreticulin | Bos taurus |
| 5 | Interestingly, gentamicin inhibited the chaperone and oxidative refolding activities of CRT when N-glycosylated substrates such as alpha1-antitrypsin and alpha-mannosidase were used as substrates, but it did not inhibit the chaperone activity of CRT when unglycosylated citrate synthase was used. | Gentamicins | calreticulin | Bos taurus |
| 6 | Interestingly, gentamicin inhibited the chaperone and oxidative refolding activities of CRT when N-glycosylated substrates such as alpha1-antitrypsin and alpha-mannosidase were used as substrates, but it did not inhibit the chaperone activity of CRT when unglycosylated citrate synthase was used. | Nitrogen | calreticulin | Bos taurus |
| 7 | Experiments with domain mutants suggest that the lectin site of CRT is the main target for gentamicin binding and that binding of gentamicin to this site inhibits the chaperone activity of CRT. | Gentamicins | calreticulin | Bos taurus |
| 8 | Experiments with domain mutants suggest that the lectin site of CRT is the main target for gentamicin binding and that binding of gentamicin to this site inhibits the chaperone activity of CRT. | Gentamicins | calreticulin | Bos taurus |