Pub. Date : 2004 Jun
PMID : 15155554
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The inhibition type of ticlopidine was found to be mixed type, with a component of mechanism-based inhibition, whereas thioTEPA inhibited CYP2B6 in a competitive manner. | Thiotepa | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | For thioTEPA the next sensitive P450 activity after CYP2B6 was coumarin 7-hydroxylation (IC(50), 256 microM). | Thiotepa | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | Thus, thioTEPA is a drug of choice when high CYP2B6 selectivity among major P450 enzymes is required. | Thiotepa | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |