Title : Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability.

Pub. Date : 2004 Apr 8

PMID : 15048091






2 Functional Relationships(s)
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1 We have shown that shortening of the poly(T)11 within the polypyrimidine stretch/accessory splicing signal of human MRE11 leads to the reduced expression and functional impairment of the MRE11/NBS1/RAD50 complex. poly(t)11 RAD50 double strand break repair protein Homo sapiens
2 We have shown that shortening of the poly(T)11 within the polypyrimidine stretch/accessory splicing signal of human MRE11 leads to the reduced expression and functional impairment of the MRE11/NBS1/RAD50 complex. polypyrimidine RAD50 double strand break repair protein Homo sapiens