Pub. Date : 1992 Apr
PMID : 1504719
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphoramidon potentiates the contractile response to endothelin-3, but not endothelin-1 in isolated airway tissue. | phosphoramidon | endothelin 3 | Homo sapiens |
| 2 | Phosphoramidon (10 microM) markedly increased the contractile response to endothelin-3 in human and rabbit bronchus in vitro. | phosphoramidon | endothelin 3 | Homo sapiens |
| 3 | In human tissue the contractile response to 0.3 microM endothelin-3 was significantly increased from 54 +/- 12% to 137 +/- 34% (of the response to 1 nM acetylcholine) in the presence of phosphoramidon. | phosphoramidon | endothelin 3 | Homo sapiens |
| 4 | These results suggest that a phosphoramidon-sensitive enzyme (probably neutral endopeptidase) found in lung, may be responsible for local degradation of endothelin-3, but not endothelin-l in human and rabbit isolated bronchus. | phosphoramidon | endothelin 3 | Homo sapiens |