Pub. Date : 1992
PMID : 1490432
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | administration of ethylcholine mustard aziridinium (AF64A) and of the monoamine oxidase (MAO)-B inhibitor L-deprenyl on the acetylcholine (ACh) biosynthetic enzyme choline acetyltransferase (ChAT), on the ACh catabolic enzyme acetylcholinesterase (AChE) and on the density of ACh muscarinic M-1 and M-2 receptor sites. | Selegiline | acetylcholinesterase | Rattus norvegicus |
| 2 | administration of ethylcholine mustard aziridinium (AF64A) and of the monoamine oxidase (MAO)-B inhibitor L-deprenyl on the acetylcholine (ACh) biosynthetic enzyme choline acetyltransferase (ChAT), on the ACh catabolic enzyme acetylcholinesterase (AChE) and on the density of ACh muscarinic M-1 and M-2 receptor sites. | Acetylcholine | acetylcholinesterase | Rattus norvegicus |
| 3 | In addition, the effect of AF64A and of L-deprenyl treatment on the localization of AChE activity in the CA-1 and CA-3 fields of the hippocampus was evaluated by combined enzyme histochemistry and microdensitometry techniques. | ethylcholine aziridinium | acetylcholinesterase | Rattus norvegicus |
| 4 | In addition, the effect of AF64A and of L-deprenyl treatment on the localization of AChE activity in the CA-1 and CA-3 fields of the hippocampus was evaluated by combined enzyme histochemistry and microdensitometry techniques. | Selegiline | acetylcholinesterase | Rattus norvegicus |
| 5 | injection of AF64A induced, 4 weeks after administration of the neurotoxin, a remarkable increase of MAO-B activity, and a significant reduction of ChAT and AChE activities in the hippocampus but not in the neostriatum which was used as a reference tissue. | ethylcholine aziridinium | acetylcholinesterase | Rattus norvegicus |
| 6 | The expression of ChAT and AChE, as well as the density of M-2 receptors, was increased after L-deprenyl administration in the hippocampus but not in the neostriatum. | Selegiline | acetylcholinesterase | Rattus norvegicus |
| 7 | An increase in AChE reactivity was noticeable in the CA-1 and CA-3 fields of the hippocampus of AF64A-injected rats treated with L-deprenyl. | Selegiline | acetylcholinesterase | Rattus norvegicus |