Title : Role of p22phox in angiotensin II and platelet-derived growth factor AA induced activator protein 1 activation in vascular smooth muscle cells.

Pub. Date : 2004 Jan

PMID : 14652666






4 Functional Relationships(s)
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1 We investigated the role of ANG II and platelet-derived growth factor (PDGF) AA induced ROS generation derived from p22phox-containing NAD(P)H oxidase in the activation of activator protein (AP) 1 in human vascular smooth muscle cells (SMCs). Reactive Oxygen Species cytochrome b-245 alpha chain Homo sapiens
2 Specific inhibition of the p22phox subunit of the NAD(P)H oxidase using either p22phox neutralizing antibody or p22phox antisense oligodeoxynucleotides (ODNs) attenuated both ANG II and PDGF AA induced ROS generation. Oligodeoxyribonucleotides cytochrome b-245 alpha chain Homo sapiens
3 Specific inhibition of the p22phox subunit of the NAD(P)H oxidase using either p22phox neutralizing antibody or p22phox antisense oligodeoxynucleotides (ODNs) attenuated both ANG II and PDGF AA induced ROS generation. Reactive Oxygen Species cytochrome b-245 alpha chain Homo sapiens
4 These findings demonstrate that AP-1 activation in human SMCs in response to ANG II and PDGF AA is mediated via generation of p22phox-dependent ROS. Reactive Oxygen Species cytochrome b-245 alpha chain Homo sapiens