Pub. Date : 2004 Jan
PMID : 14592851
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Decreased macrophage paraoxonase 2 expression in patients with hypercholesterolemia is the result of their increased cellular cholesterol content: effect of atorvastatin therapy. | Cholesterol | paraoxonase 2 | Homo sapiens |
| 2 | Decreased macrophage paraoxonase 2 expression in patients with hypercholesterolemia is the result of their increased cellular cholesterol content: effect of atorvastatin therapy. | Atorvastatin | paraoxonase 2 | Homo sapiens |
| 3 | OBJECTIVE: To analyze paraoxonase2 (PON2) expression in human monocyte-derived macrophages (HMDM) from patients with hypercholesterolemia in relation to cellular cholesterol and oxidative stress. | Cholesterol | paraoxonase 2 | Homo sapiens |
| 4 | OBJECTIVE: To analyze paraoxonase2 (PON2) expression in human monocyte-derived macrophages (HMDM) from patients with hypercholesterolemia in relation to cellular cholesterol and oxidative stress. | Cholesterol | paraoxonase 2 | Homo sapiens |
| 5 | CONCLUSIONS: HMDM-PON2 expression is reduced in patients with hypercholesterolemia as a result of their increased cellular cholesterol content. | Cholesterol | paraoxonase 2 | Homo sapiens |
| 6 | Atorvastatin therapy reduced both macrophage oxidative stress and cholesterol content, and upregulated PON2 expression, thus contributing to attenuation of foam cells formation. | Atorvastatin | paraoxonase 2 | Homo sapiens |