Pub. Date : 1992
PMID : 1459041
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In all experiments, rats were given PYR (131 micrograms/kg, im; I70 dose for whole blood AChE) or vehicle 30 min prior to nerve agent. | Pyridostigmine Bromide | acetylcholinesterase | Rattus norvegicus |
| 2 | In assessing therapeutic efficacy and oxime-induced reactivation of blood AChE, rats were pretreated with PYR, challenged with agent and treated with atropine (16 mg/kg, im) and HI-6 or 2-PAM (100 umoles/kg, im) 30 sec post agent. | Oximes | acetylcholinesterase | Rattus norvegicus |
| 3 | Also, AChE reactivation by HI-6 in VX-challenged rats was greater (p < .05) in vehicle- than in PYR-pretreated rats. | asoxime chloride | acetylcholinesterase | Rattus norvegicus |
| 4 | HI-6 significantly reactivated AChE activity in both pretreatment groups (PYR or vehicle) given soman. | asoxime chloride | acetylcholinesterase | Rattus norvegicus |
| 5 | The data suggest that PYR decreases the overall recovery of inhibited AChE in VX-challenged rats given HI-6; under the conditions used, this adverse effect decreases atropine+oxime efficacy against VX-induced lethality. | asoxime chloride | acetylcholinesterase | Rattus norvegicus |
| 6 | The data suggest that PYR decreases the overall recovery of inhibited AChE in VX-challenged rats given HI-6; under the conditions used, this adverse effect decreases atropine+oxime efficacy against VX-induced lethality. | VX | acetylcholinesterase | Rattus norvegicus |