Title : Antiproliferative potencies of interferons on melanoma cell lines and xenografts: higher efficacy of interferon beta.

Pub. Date : 1992 Aug 5

PMID : 1378904






5 Functional Relationships(s)
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1 We did this comparison by determining the concentration of each IFN that resulted in 50% growth inhibition, using the MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium tetrazolium bromide] dye uptake method. monooxyethylene trimethylolpropane tristearate interferon alpha 1 Homo sapiens
2 We did this comparison by determining the concentration of each IFN that resulted in 50% growth inhibition, using the MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium tetrazolium bromide] dye uptake method. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2h-tetrazolium tetrazolium bromide interferon alpha 1 Homo sapiens
3 Receptor binding was determined using [35S]methionine-labeled IFN alpha-4a, in competition with unlabeled IFN alpha-2b, IFN alpha-4a, and IFN-beta. Sulfur-35 interferon alpha 1 Homo sapiens
4 Receptor binding was determined using [35S]methionine-labeled IFN alpha-4a, in competition with unlabeled IFN alpha-2b, IFN alpha-4a, and IFN-beta. Methionine interferon alpha 1 Homo sapiens
5 Similarly, IFN-beta was more potent than IFN alpha-2a in inhibiting the growth of the LiBr xenograft in nude mice. lithium bromide interferon alpha 1 Homo sapiens