Pub. Date : 1992 Sep
PMID : 1357223
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-beta. | Glucose | transforming growth factor, beta 1 | Mus musculus |
| 2 | Several lines of evidence indicated that the late phase of glucose-induced growth inhibition was mediated by the bioactivation of endogenous transforming growth factor beta (TGF-beta). | Glucose | transforming growth factor, beta 1 | Mus musculus |
| 3 | Neutralizing antibody against TGF-beta prevented the late inhibitory effects of glucose on proliferation. | Glucose | transforming growth factor, beta 1 | Mus musculus |
| 4 | Furthermore, Northern blot analysis revealed that TGF-beta 1 mRNA was induced by 450 mg/dl glucose in the medium after 48 to 72 hours, but not after 24 hours. | Glucose | transforming growth factor, beta 1 | Mus musculus |
| 5 | However, the addition of neutralizing anti-TGF-beta antibody stimulated the progression of cells towards S-G2 in high glucose medium after 48 hours. | Glucose | transforming growth factor, beta 1 | Mus musculus |
| 6 | This inhibition may be mediated by the glucose-induced synthesis and/or bioactivation of TGF-beta which can inhibit proliferation of mesangial cells in an autocrine fashion. | Glucose | transforming growth factor, beta 1 | Mus musculus |