Title : Putative neurotoxicity of SKF 38393 and other D1 dopaminergic drugs investigated in rat striatum.

Pub. Date : 1992 Apr

PMID : 1347781






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 First, unilateral intrastriatal microinjection of the excitotoxin kainic acid (2 micrograms in 1 microliter) was shown to evoke vigorous contraversive circling, followed 1 or 2 weeks later by profound decreases in striatal AChE (24 and 54%), GAD (51 and 75%), and protein (36 and 47%), as well as loss of GAD (45% at 2 weeks) in the ipsilateral substantia nigra. Kainic Acid acetylcholinesterase Rattus norvegicus