Title : Changes in the plasma levels and basic pharmacokinetic parameters of digoxin used in combination with gentamicin, amiodarone and spironolactone.

Pub. Date : 1992

PMID : 1339769






7 Functional Relationships(s)
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Protein Name
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1 caused elevation of plasma digoxin levels primarily because the alpha half-life was prolonged (t1/2 alpha). Digoxin interleukin 1 receptor like 1 Homo sapiens
2 ), and of digoxin with amiodarone, the plasma levels of digoxin rose due to the lengthened beta half-life (t1/2 beta). Digoxin interleukin 1 receptor like 1 Homo sapiens
3 In administering a combination of digoxin and spironolactone, the plasma digoxin levels dropped, t1/2 alpha decreased and t1/2 beta increased. Digoxin interleukin 1 receptor like 1 Homo sapiens
4 In administering a combination of digoxin and spironolactone, the plasma digoxin levels dropped, t1/2 alpha decreased and t1/2 beta increased. Spironolactone interleukin 1 receptor like 1 Homo sapiens
5 The digoxin level was elevated with the combinations of digoxin-amiodarone and digoxin-spironolactone: t1/2 alpha was longer in both cases, while t1/2 beta was longer only for the digoxin-amiodarone combination. Digoxin interleukin 1 receptor like 1 Homo sapiens
6 The digoxin level was elevated with the combinations of digoxin-amiodarone and digoxin-spironolactone: t1/2 alpha was longer in both cases, while t1/2 beta was longer only for the digoxin-amiodarone combination. Amiodarone interleukin 1 receptor like 1 Homo sapiens
7 The digoxin level was elevated with the combinations of digoxin-amiodarone and digoxin-spironolactone: t1/2 alpha was longer in both cases, while t1/2 beta was longer only for the digoxin-amiodarone combination. digoxin-spironolactone interleukin 1 receptor like 1 Homo sapiens